Cardiovascular Biomechanics Lab

Publications

Hiebing A.A., Pieper R. G., Witzenburg C.M.: A Computational Model of Ventricular Dimensions and Hemodynamics in Growing Infants. Journal of Biomechanical Engineering, (2023).

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•  ASME Digital Collection: link

Pearce D.P., Nemcek M.T., Witzenburg C.M.: Don’t go breakin’ my heart: cardioprotective alterations to the mechanical and structural properties of reperfused myocardium during post‑infarction infammation. Biophysical Reviews, (2023).

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•  SpringerNature: link

Pearce D., Nemcek M., Witzenburg C.: Combining Unique Planar Biaxial Testing with Full-Field Thickness and Displacement Measurement for Spatial Characterization of Soft Tissues. Current Protocols, (2022).

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•  PMID: 35849021

Caggiano L.R., Holmes J.W., Witzenburg C.M.: Individual variability in animal-specific hemodynamic compensation following myocardial infarction. Journal of Molecular and Cellular Cardiology, (2021).

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•  PMID: 34756992

Shih E., Provenzano P., Witzenburg C.M., Barocas, V.H., Grande A., Alford, P.W.: Characterizing Tissue Remodeling and Mechanical Heterogeneity in Cerebral Aneurysms. Journal of Vascular Research, (2021).

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•  PMID: 34758464

Witzenburg, C.M., Holmes, J.W.: The Impact of Hemodynamic Reflex Compensation Following Myocardial Infarction on Subsequent Ventricular Remodeling. Journal of Biomechanical Engineering. 141:9, 091010, (2019).

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•  PMID: 31141599
•  Full Text

Kim A.S., Witzenburg C.M., Conaway M.R., Vergales J.E., Holmes J.W., L’Ecuyer T.J., Dean P.N.: Trajectory of right ventricular indices is an early predictor of outcomes in hypoplastic left heart syndrome. Congenital Heart Disease. 14:6, 1185-1192, (2019).

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•  PMID: 31393088
•  Full Text

Witzenburg, C.M., Holmes, J.W.: Predicting the time course of ventricular dilation and thickening using a rapid compartmental model. Journal of Cardiovascular Translational Research. 11:2, 109-122, (2018).

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•  PMID: 29550925
•  Full Text
•  Clinical Applications of Patient-Specific Models: The Case for a Simple Approach

Graphs showing experimental and model predictions of ventricular growth following pressure and volume overload.

Witzenburg, C.M., Holmes, J.W.: A Comparison of Phenomenologic Growth Laws for Myocardial Hypertrophy. Journal of Elasticity. 129:1-2, 257-81, (2017).

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•  PMID: 29632418
•  Full Text

Witzenburg, C.M., Holmes, J.W.: Biomechanics of Myocardial Ischemia and Infarction. In: Ogden, R.W. and Holzapfel, G.A. (ed.) Biomechanics: Trends in Modeling and Simulation. Springer, New York, 20, 233-269, (2017).

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•  Series: Studies in Mechanobiology, Tissue Engineering and Biomaterials
•  In: Biomechanics: Trends in Modeling and Simulation
•  Full Text

Illustration of differences in collagen fiber alignment in histologic sections taken from the center of the infarct scar in different experimental models and imaged under polarized light.
Displacement of a representative shear lap sample, stress versus grip stretch for circumferentially orientated samples, and model results with shear stress distribution along the axis of applied deformation for a circumferentially aligned sample.

Witzenburg, C.M., Dhume, R.H., Shah, S.B., Korenczuk, C.E., Wagner, H.P., Alford, P.W., Barocas, V.H.: Failure of the Porcine Ascending Aorta: Multidirectional Experiments and a Unifying Microstructural Model. Journal of Biomechanical Engineering. 139, 31005–3 (2017).

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•  PMID: 27893044
•  Full Text

Witzenburg, C.M., Barocas, V.H.: A nonlinear anisotropic inverse method for computational dissection of inhomogeneous planar tissues. Computer Methods in Biomechanics and Biomedical Engineering. 19:15, 1630-46, (2016).

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•  PMID: 27140845
•  Full Text

Strain energy determined by the nonlinear GAIM method for all extensions plotted in strain space for both the element within the inclusion and the element just outside the inclusion.

Witzenburg, C.M., Dhume, R.Y., Lake, S.P. and Barocas, V.H., Automatic Segmentation of Mechanically Inhomogeneous Tissues Based on Deformation Gradient Jump. IEEE Transactions of Medical Imaging. 35:1, 29-41, (2016).

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•  PMID: 26168433
•  Full Text

Shah, S. B., Witzenburg, C.M., Hadi, M. F., Wagner, H. P., Goodrich, J. M., Alford, P. W., & Barocas, V. H. Prefailure and Failure Mechanics of the Porcine Ascending Thoracic Aorta: Experiments and a Multiscale Model. Journal of Biomechanical Engineering, 136:2, 021028, (2014).

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•  PMID: 24402447
•  Full Text

Model circumferential Green strain along the axis of pull plotted over the deformed model mesh.
Rat heart during decellularization. Sketch of sample geometry overlaid on fully decellularized rat heart, showing the circumferential and longitudinal directions.

Witzenburg, C.M., Raghupathy, R., Kren, S. M., Taylor, D. A. & Barocas, V. H. Mechanical Changes in the Rat Right Ventricle with Decellularization. Journal of Biomechanics, 45:5, 842-9, (2012).

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•  PMID: 22209312
•  Full Text

Raghupathy, R., Witzenburg, C.M., Lake, S. P., Sander, E. A., & Barocas, V. H. Identification of regional mechanical anisotropy in soft tissue analogs. Journal of Biomechanical Engineering, 133:9, 091011, (2011).

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•  PMID: 222010746
•  Full Text
•  Robust Image Correlation Based Strain Calculator for Tissue Systems

Comparison of alignment maps generated by the model and polarized light microscopy for 7-day and 11-day tissue engineered samples.